GHK-Cu
Also known as: Copper peptide · Glycyl-L-histidyl-L-lysine copper
GHK-Cu is most relevant as an over-the-counter skin-care ingredient. Injectable or systemic use is a different question and should be treated with much more caution.
Good evidence for topical wound healing and collagen synthesis. Multiple trials show skin improvement. OTC topical serums have solid evidence. Injectable systemic effects are less studied.
What to know before you go deeper
Naturally occurring copper complex that declines with age. Promotes collagen and elastin synthesis, acts as a powerful antioxidant, and has wound-healing properties. Topically well-penetrating.
Approval status: OTC. Read the details before assuming it fits your situation.
Skin tightening after weight loss, Collagen production, Wound healing.
What evidence applies to my situation, what monitoring is needed, and what safer first steps should I try?
Why People Ask About GHK-Cu
- Skin tightening after weight loss
- Collagen production
- Wound healing
- Hair follicle stimulation
- Anti-aging skin care
Questions to Bring Up
Topical cosmetic use follows the product label. Injectable or systemic use is a research-only topic and should not be self-directed.
Dosing, sourcing, and suitability questions belong with a licensed clinician who can review your history, labs, medications, and goals.
Known Side Effects
- Topical: skin irritation, temporary discoloration
- Injectable: injection site reactions
- Generally very safe profile
Important Safety Notes
Highly relevant for GLP-1 users experiencing skin laxity after rapid weight loss
One of the few peptides with solid OTC topical evidence
Injectable GHK-Cu is research use — topical is OTC
Pairs well with collagen supplements and vitamin C
What Is Approved?
Available OTC as a cosmetic ingredient and in some supplement forms. Topical use is unregulated. Injectable use is research only.
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