Constipation and Gut Motility on GLP-1s
Constipation affects roughly 25–30% of people on GLP-1 medications. It's uncomfortable and often underreported — but it's very manageable with the right approach.
Why It Happens
GLP-1 medications slow gastric emptying and reduce gut motility — the muscular contractions that move food through your digestive tract. Combined with reduced food intake (less bulk) and sometimes reduced fluid intake due to nausea, constipation is a predictable downstream effect.
Practical Strategies
- Increase soluble fiber gradually. Psyllium husk is one of the most evidence-backed options. Start low, go slow.
- Hydration is critical — fiber without adequate water makes constipation worse. Aim for 8+ cups daily.
- Move your body. Even a 20-minute walk after meals stimulates gut motility.
- Establish a consistent bathroom routine — try sitting after your morning coffee or meal when gut motility is naturally higher.
- Magnesium citrate (200–400mg at night) is widely used as a gentle osmotic laxative. Discuss with your provider.
- Avoid over-relying on stimulant laxatives (like senna) regularly — they can reduce natural gut function over time.
Products That May Help
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Questions to Ask Your Clinician
Bring these to your next appointment. Your prescriber is your best resource for decisions specific to your situation.
- "How many days without a bowel movement should prompt me to contact you?"
- "Is magnesium citrate appropriate for me given my other medications?"
- "Would a referral to a gastroenterologist be appropriate if this persists?"
- "Are there any medications I'm taking that could be worsening my constipation?"
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